The workup for the suspected MEN syndrome revealed an increased basal plasma level of insulin-like growth factor-1 (430 ng/ml; normal range, 124–290 ng/ml), prolactin (43.9 ng/ml; normal range, 3–25 ng/ml) and calcitonin (286.3 pg/ml; normal range, <10 pg/ml), and an increased 24-h urinary free cortisol level (563.5 μg/24 h; normal range, 55.5–286.0). This evidence concerns the gene IGF1 and multiple endocrine neoplasia.