The pathological diagnosis of the resected breast was of an invasive ductal carcinoma associated with ductal carcinoma in situ demonstrating estrogen receptor (ER)-positive, progesterone receptor-positive and HER2/neu proliferation-negative breast cancer, and metastatic carcinoma was detected in the right axillary lymph nodes (Fig. 3). Here, ERBB2 is linked to invasive ductal breast carcinoma.