The pathological diagnosis of the resected breast was of an invasive ductal carcinoma associated with ductal carcinoma in situ demonstrating estrogen receptor (ER)-positive, progesterone receptor-positive and HER2/neu proliferation-negative breast cancer, and metastatic carcinoma was detected in the right axillary lymph nodes (Fig. 3). This evidence concerns the gene ERBB2 and ductal breast carcinoma in situ.