The patient exhibited major clinical manifestations of MEN1, such as primary hyperparathyroidism, pituitary adenoma and pancreatic endocrine carcinoma together with other tumors, including adrenocortical adenoma, a thymic carcinoid tumor, papillary thyroid carcinoma, uterine leiomyoma, lung hamatoma and breast cancer. The gene discussed is MEN1; the disease is primary hyperparathyroidism.