Therefore, the present study focused on bMSC-derived Wnt5a to investigate its effect on the growth of leukemia HL60 cells and to determine which factor or factors alter the proliferation and maturation of HL60 cells, and whether Wnt5a or other factors are altered as a result of the overexpression of Wnt5a in bMSCs. Here, WNT5A is linked to leukemia.