The important genes that are involved in developmental and neurological disorders are GABRA5, GABRA3, GABRG3, MAGEL2, MKRN3, NDN, SNRPN and UBE3A. Three of the genes encode subunits of the GABA receptors, a family of ligand-gated chloride channels which mediate the major inhibitory neurotransmitter GABA in the brain. This evidence concerns the gene MAGEL2 and nervous system disorder.