TP53 and cancer: N. sativa plays a major role in anticipation of cancer via the induction of proapoptotic factors Bak/Bax or downregulation of antiapoptotic proteins Bcl-2 and Bcl-xL that cause the activation of caspase in cancer cell without alteration in normal cells. Nigella sativa and its constituents TQ showed vital effects as anticancer and also trigger apoptotic cell death in human colorectal cancer via a p53-dependent mechanism [55, 64].