We found, as recent literature has proposed [24], a different level of this central component of cell junctions-adhesion molecule: plasmalemmal positivity in the normal tissue and in the transition area from stratified squamous epithelium to neoplastic budding with occasionally negative neoplastic cells; we observed a gradual decreasing of e-cad positivity into neoplasia, with focally negative neoplastic glands. The gene discussed is CDH1; the disease is neoplasm.