Epidemiological studies have demonstrated that curcumin is responsible for the significantly reduced (4.4-fold) prevalence of AD in India, compared to United States (Calabrese et al., 2007b, 2008b; Mancuso et al., 2007a), and curcumin given chronically in the diet to transgenic APPSw, a mouse model (Tg2576) of AD suppresses brain inflammatory and oxidative damage, an effect associated to inhibition of nuclear factor-κB (NF-κB) and efficient prevention of neuronal cell death (Calabrese et al., 2009b,d, 2010d,h; Gupta et al., 2011). The gene discussed is NFKB1; the disease is Alzheimer disease.