The pathological hallmarks of AD are amyloid plaques, formed of Aβ peptide derived from the transmembrane amyloid precursor protein (APP; Siciliano et al., 2011), and neurofibrillary protein tangles, composed of hyperphosphorylated tau, in the temporal lobe and some other brain cortical regions associated with death of neuronal cells and synaptic depletion (Hardas et al., 2013). Here, MAPT is linked to Alzheimer disease.