MAPT and Alzheimer disease: Alzheimer’s disease (AD) is characterized by progressive deterioration of cognitive functions and stress (Calabrese et al., 2006d), with biochemical alterations consisting in the accumulation of amyloid-β (Aβ) protein in the form of senile plaques and intracellular neurofibrillary tangles, associated with hyperphosphorylated tau protein and neuronal cell depletion (Liu and Chan, 2014).