Later analysis showed that of the patients that showed an antibody response to the Aβ antigen, several (seven patients analyzed) showed significant clearing of hippocampal Aβ plaque and reduced plaque density as well as reduced phosphorylated tau compared to non-treated AD patients (Masliah et al., 2005; Serrano-Pozo et al., 2010). Here, MAPT is linked to Alzheimer disease.