Consistent with the marked reduced level of IL-23 in the BALF, the administration of anti-HMGB1 IgG also significantly suppressed the production of IL-23, which is an important cytokine that is used to differentiate and promote the Th17 response [24], by lung CD11c+ APCs (P < 0.05 versus Asthma group or IgG group, Figure 7). This evidence concerns the gene HMGB1 and asthma.