The genes of ABCG2, CA7, HP, KIAA1199, and CLDN1 are upregulated and CA4, CHP2, CHST5, CLCA1, CLCA4, CLDN8, FAM55D, H3F3A, MUC2, and NR3C2 are downregulated in carcinoma and metastases, which can be prognosis monitoring markers. The gene discussed is CA4; the disease is carcinoma.