Regarding the effect of lipodystrophy on the association between anthropometric and metabolic parameters in HIV-infected patients, a significant positive correlation was found between leptin and: insulin at 2 hours on OGTT; total, trunk, leg, arm fat evaluated by DXA; and total, SAT, VAT/SAT ratio on abdominal level evaluated by CT scan in these patients, regardless of the presence of FMR-L. The gene discussed is INS; the disease is lipodystrophy.