The aim of this study was to evaluate the relationship between fat mass, lipodystrophy defined by the Fat Mass Ratio (FMR-L) and the four different categories of fat distribution, and adipocyte derived hormones (adiponectin, leptin, resistin, TNF-α), orexigenic hormones (ghrelin), prothrombotic factors (PAI-1) and IR in HIV-infected patients on cART. Here, TNF is linked to lipodystrophy.