Findings of abnormal function or loss of adipose tissue in partial lipodystrophy syndromes (due to lamin A/C or to PPAR-γ receptor mutations) and low adiponectinemia also support the hypothesis that low adiponectin concentrations in HIV-infected subjects with low levels of SAT are due to lipodystrophy per se[39,40]. This evidence concerns the gene ADIPOQ and lipodystrophy.