Catalytic mutations in TET2, but not TET1, are commonly identified in patients with hematopoietic disorders and malignancies such as myelodysplastic syndrome, myeloproliferative neoplasms, acute myelogenous leukemia, chronic myelomonocytic leukemia, and B-cell and T-cell lymphomas [38-42]. Here, TET2 is linked to acute myeloid leukemia.