CD2AP and Alzheimer disease: The Apolipoprotein E E4 allele increases the risk of AD by 3- to 15-fold, although several genetic loci (CLU, PICALM, CR1, BIN1, MS4A, CD2AP, CD33, EPHA1, ABCA7, CD2AP, HLA-DRB5/DRB1, SORL1, PTK2B, SLC24A4, ZCWPW1, CELF1, FERMT2, CASS4, INPP5D, MEF2C, NME8) have a low effect on disease risk (Guerreiro et al., 2013a).