PSEN1 and dementia: The analysis of the exome sequencing data confirmed the absence of pathogenic mutations in APP, PSEN1, and PSEN2. Additionally, no coding variants were found in the dementia associated genes APP, PSEN2, GRN, TREM2, or PLD3. The patient was found to carry the PSEN1 (NM_000021) p.E318G and the MAPT (NM_001123066) p.Q230R variants.