Also, HF-fed Nrf2−/− mice exhibited a greater decrease in blood glucose during insulin tolerance tests (ITT) than Nrf2+/+ mice, an outcome not observed for RC-fed mice (Fig. 2F and G); importantly, the ITT for HF-fed Nrf2−/− mice had to be curtailed after 60 min, as ∼50% of them did not mount a counterregulatory response to insulin-induced hypoglycemia and had to be given glucose to recover. Here, NFE2L2 is linked to hydrops fetalis.