Reticulin staining revealed that HF-fed Nrf2+/+ livers contained significantly increased amounts of type III collagen compared with their RC-fed counterparts and that RC-fed Nrf2−/− mouse livers had levels of type III collagen similar to those of Nrf2+/+ mice on the same diet (data not shown). The gene discussed is NFE2L2; the disease is hydrops fetalis.