NR1H3 and fatty liver disease: First, we examined the mRNA levels of the following transcription factors that contribute to liver steatosis: Srebf1 and Srebf2, which regulate cholesterol biosynthesis; Mlxipl, which regulates triglyceride synthesis genes in a glucose-dependent manner; PPARγ, which promotes storage of FA; LXRα and LXRβ, which control lipid homeostasis and inflammation; Frx, which regulates cholesterol and bile acid production; and Shp, which represses LXR (for reviews, see references 60 to 64).