Intriguingly, the findings that Ampkβ1−/− mice are protected from HF diet-induced steatosis (74) and that Ampkβ1 (i.e., Prkab1) is upregulated in Nrf2−/− mice (31) suggest that it may contribute to exacerbation of steatosis in Nrf2−/− liver. This evidence concerns the gene NFE2L2 and steatosis.