The hypothesis that Nrf2−/− livers have less intrinsic antioxidant capacity than Nrf2+/+ livers is supported by the fact that levels of mRNAs for Txnrd1, which reduces oxidized thioredoxin, and Srxn1, which reactivates overoxidized peroxiredoxin, are significantly lower in RC- and HF-fed Nrf2−/− livers (Fig. 9C). Here, TXN is linked to hydrops fetalis.