The expression of the NF-κB target genes Cox2 and Nos2 was increased by 12- and 6-fold, respectively, in HF-fed Nrf2+/+ livers and by 23- and 60-fold, respectively, in livers of HF-fed Nrf2−/− mice (Fig. 7D). This evidence concerns the gene NFE2L2 and hydrops fetalis.