Global knockout of Nrf2 profoundly increases the susceptibility of mice to NASH when they are placed on a methionine- and choline-deficient (MCD) diet (33, 34), whereas genetic activation of Nrf2 by knockdown of Keap1 decreases their sensitivity to NASH caused by the MCD diet (35). This evidence concerns the gene KEAP1 and metabolic dysfunction-associated steatohepatitis.