Ultrastructural analysis showed normal architecture for RC-fed Nrf2+/+ livers, with fat globules present in hepatocytes from HF-fed Nrf2+/+ and RC-fed Nrf2−/− mice, whereas hepatocytes of HF-fed Nrf2−/− mice were characterized by swollen mitochondria with reduced crista and disrupted membranes (Fig. 3F). The gene discussed is NFE2L2; the disease is hydrops fetalis.