However, HF-fed Nrf2−/− livers demonstrated increases in mRNAs for Acly, Acaca, Fasn, Elovl5, Elovl6, and Fabp5 that were significantly greater than those observed in HF-fed Nrf2+/+ livers but had no effect on Fabp1. This evidence concerns the gene ELOVL5 and hydrops fetalis.