NFE2L2 and hydrops fetalis: When fed an HF diet, mass accumulation was less apparent in Nrf2−/− mice (Fig. 1B and C), with a mean increase in body mass of 14.5 ± 1.3 g (n = 10) and 10.7 ± 1.1 g (n = 11; P < 0.05) for Nrf2+/+ and Nrf2−/− mice, respectively.