HMGCR and hydrops fetalis: HF feeding did not increase plasma triglycerides or FA levels in either genotype (data not shown) but increased plasma cholesterol in both genotypes; Nrf2−/− mice exhibited lower cholesterol on either diet than Nrf2+/+ mice (Fig. 3G), and this is most likely due to inactivation of the redox-sensitive HMG CoA reductase in the mutant mouse by higher ROS levels (59).