However, HF-fed Nrf2−/− livers exhibited significant increases in mRNAs for Srebf1, Srebf2, Mlxipl, and PPARγ, with no change in mRNA for LXRα and reduced levels of mRNAs for Shp, LXRβ, and FXR (Fig. 4A). This evidence concerns the gene SREBF1 and hydrops fetalis.