The heightened upregulation of Fabp5, Acly, Acaca, Fasn, and Elovl6 in Nrf2−/− livers in response to the HF diet is likely to be due to the increased expression of the transcription factors Srebf1, Srebf2, Mlxipl, and PPARγ compared with that in HF Nrf2+/+ livers. Here, ACLY is linked to hydrops fetalis.