The nuclear abundance of the NF-κB p65 RelA subunit was increased in livers of HF-fed Nrf2+/+ and RC-fed Nrf2−/− mice, with the HF diet raising NF-κB p65 levels in Nrf2−/− livers even further (Fig. 7C). The gene discussed is NFE2L2; the disease is hydrops fetalis.