Global knockout of Nrf2 profoundly increases the susceptibility of mice to NASH when they are placed on a methionine- and choline-deficient (MCD) diet (33, 34), whereas genetic activation of Nrf2 by knockdown of Keap1 decreases their sensitivity to NASH caused by the MCD diet (35). The gene discussed is NFE2L2; the disease is metabolic dysfunction-associated steatohepatitis.