The possible involvement of MARCH6 in the ERAD pathway in liver disease and metabolism has been suggested by recent studies demonstrating that MARCH6 ubiquitinates type 2 iodothyronine deiodinase (DIO2) and the mutant bile salt pump (Bsep)/ABCB11 associated with familial intraheoatic cholestasis type I for proteasomal degradation [95,96]. The gene discussed is DIO2; the disease is liver disorder.