When history of arrhythmias, AF, CS, CRP, diabetes, hypercholesterolemia, hypertension, hypertriglyceridemia, and history of MI were forced into Cox regression model, the association between FGB −455 A-allele and worse survival persisted, however wider CIs were observed reflecting smaller sample size (non-smoker HR = 41.0, 95% CI: 3.23-520, p = 0.004; smoker HR = 37.2, 95% CI: 2.50-548, p = 0.009). The gene discussed is FGB; the disease is Hypercholesterolemia.