In particular, MSI colon cancers are associated with increased intraepithelial CD8+ T cells when compared to microsatellite stable (MSS) cancers [8]–[10], and many MSI cancers demonstrate a “Crohn's-like” lymphoid “granuloma” reaction histologically within the epithelial component of the adenocarcinoma [7]–[9]. The gene discussed is CD8A; the disease is cancer.