A single DPB1 amino acid, glutamic acid at position 69, has been shown to contribute to graft-versus-host disease in otherwise identical HLA sibling bone marrow transplantation[29] and factor in the susceptibility to Beryllium disease.[24], [26] However, the frequency of glutamic acid at position 69 in our patients with AIH and controls was 35% and 39%, respectively. The gene discussed is HLA-DPB1; the disease is graft versus host disease.