Consistent with this is a previous study in chronic persistent severe asthma (n = 9) which demonstrated increased mRNA expression of the innate immune receptors TLR2, TLR4 and CD14, as well as the cytokines IL-8 and IL-1β in induced sputum from patients with neutrophilic asthma [11]. The gene discussed is CXCL8; the disease is asthma.