In the univariate analysis (Table 2), tumor size, Fuhrman grade, TNM stage and LASP-1 upregulation were significantly correlated with poor overall survival (P = 0.034, <0.0001, <0.0001 and  = 0.003, respectively) and recurrence-free survival (P = 0.005, <0.0001, <0.0001 and <0.0001, respectively) in ccRCC patients. This evidence concerns the gene LASP1 and nonpapillary renal cell carcinoma.