The multivariate analysis revealed that Fuhrman grade, TNM stage, and LASP-1 upregulation were independent prognostic factors for overall survival (P = 0.001, <0.0001 and 0.044, respectively) and recurrence-free survival (P = 0.002, 0.010 and 0.006, respectively) in ccRCC patients (Table 3). The gene discussed is LASP1; the disease is nonpapillary renal cell carcinoma.