We hypothesized that glucocorticoid-induced muscle atrophy might be linked to the expression and regulation of TRAF6. To test the hypothesis, in this study, we examined the expression of TRAF6 in dexamethasone-induced muscle atrophy under in vivo and in vitro conditions, and further investigated the regulating effect of TRAF6 on myotube/muscle atrophy using knockdown experiments. The gene discussed is TRAF6; the disease is Atrophy.