In the Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction 48 (ENGAGE AF-TIMI 48) trial, 21,105 patients with non valvular AF were randomized to adjusted-dose warfarin or two doses (30 mg q.d., 60 mg q.d.)of edoxaban [6]. This evidence concerns the gene F10 and atrial fibrillation.