MDM2 and hepatocellular carcinoma: The data from our study has demonstrated that MDM2 is a potential TAA in HCC, and the anti-MDM2 autoantibodies may be used as a biomarker in early stage HCC diagnosis because a higher titer of autoantibodies against MDM2 in ELISA can be seen in sera at 6 months to 9 months before the clinical diagnosis of HCC.