Even if at this time there are no in silico studies on the role of rs1064395 SNP in BD risk, based on our expertise in computational mutagenesis and quantitative structure-activity relationship (QSAR) applied to peptides and proteins [79, 80], we may suggest that the critical molecular features for the biological activity of NCAN native and its mutants should be represented by van der Waals surface and/or solvent accessible surface areas [81, 82] or count of atoms and bound types (e.g., polar and hydrophobic atoms, rigid and rotatable bonds) [83]. The gene discussed is NCAN; the disease is Behcet disease.