Our results suggest a positive association between the XPD Lys751Gln variant homozygous (Gln/Gln) and combined heterozygous + homozygous variant genotypes (Lys/Gln + Gln/Gln) and the risk of CML. This evidence concerns the gene ERCC2 and chronic myelogenous leukemia, BCR-ABL1 positive.