The XRCC1 Arg194Trp, XRCC1 Arg280His, XRCC1 Arg399Gln, XRCC3 Thr241Met, and XPD Lys751Gln polymorphisms studied had no influence on the risk of CML with respect to gender. This evidence concerns the gene XRCC1 and chronic myelogenous leukemia, BCR-ABL1 positive.