CD8A and neoplasm: The tumor suppression in our mice may have arisen from the interplay between iNKT cells and CD8+ T cells, with the early activation of NKT cells facilitating the expansion of tumor specific CD8+ T cells; whereas, in their model, type I NKT cells may be playing an immunoregulatory role and that this model may induce a potent CD8+ T cell responses that iNKT cells are attempting to down regulate.