SOD2 and familial pancreatic carcinoma: Genes which detoxify superoxide (superoxide dismutases 2 and 3) and which prevent the generation of hydroxyl radical (ferroxidase/ceruloplasmin) were found to be upregulated in SU86.86 pancreatic cancer cells in prior work [18] and in this study (Table 1), and in each of four ovarian cancer cell lines [25] through Mirk.