DYRK1B and familial pancreatic carcinoma: To identify antioxidant genes which were downregulated when Mirk levels were depleted, we utilized SU86.86 pancreatic cancer cells stably expressing a doxycycline-inducible shRNA to Mirk, in which ROS levels previously had been shown to increase when Mirk was depleted about 8 to 10-fold [18].