The identification of a CNV that involved WWOX in two unrelated patients (see Table 6, Figures 1 and 2) was of interest as this gene is located in a fragile site (FRA16D) associated with cancer development and has been shown to interact with TP53 and ACK1[33] and has recently been reported to be involved in breast carcinogenesis [34,35]. The gene discussed is TP53; the disease is cancer.