In agreement with the significantly higher testosterone concentrations we observed in MetS patients than in controls, a Chinese study of 719 women with polycystic ovary syndrome and 685 healthy volunteers found that patients with polycystic ovary syndrome and obesity had higher serum testosterone and fasting insulin levels, lower LH levels, and enlarged ovarian follicles compared with control subjects [24]. This evidence concerns the gene PLOD1 and metabolic syndrome.