All of the seven transcription factors predicted to be activated by IPA and reported to drive GADD45A expression in the literature: breast cancer 1, early onset (BRCA1), forkhead box O3 (FOXO3 or FKHRL1), forkhead box O4 (FOXO4 or AFX1), myogenic differentiation 1 (MYOD1), tumor protein p53 (TP53) (see also Figures 5–6), tumor protein p63 (TP63) and tumor protein p73 (TP73) have been shown to be involved with apoptosis[68-74]. The gene discussed is TP53; the disease is breast carcinoma.