PROM1 and malignant colon neoplasm: For instance, Yang et al. have demonstrated that the homeostasis between CSCs (CD133+) and CCs (CD133−) in the Swan620 colon cancer cells was disturbed by radiation (gamma-ray, 2 Gy, 6 Gy, or 2 Gy × 3), which reached a final dynamic equilibrium about 18 days after irradiation [37].