PARP1 and intestinal cancer: The observed negative correlation between nicotinamide concentration levels and polyp numbers (Table 3, Figure 2C), along with the numerous known relations of nicotinamide to genes of the PARP family that were revealed in our data (Figure 3A), suggest a possible antagonist effect of nicotinamide compound levels on polyp formation and on promotion of intestinal cancer via inhibition of PARP activity.