Because mutations in Adenomatous Polyposis Coli (APC) was observed in over 80% of sporadic human colon cancer cases [44-46], ApcMin/+ mice carrying a dominant mutation in the Apc gene commonly serve as the mouse model of choice for the human Familial Adenomatous Polyposis (FAP) syndrome. Here, APC is linked to Familial adenomatous polyposis.