APC and hydrops fetalis: First, looking further into individual long chain acyl-CoAs, note that the effect of high fat feeding is associated with an increase of specific long chain acyl-CoAs contents, namely C12-CoAs and to a lower extent C14-CoAs, in both Apc genotype backgrounds: We report in Apc wild-type and ApcMin/+ mutant animals, both fed with high fat, a significant fold change increase of C12-CoAs content as compared to all other long chain acyl-CoAs contents (WT-HF group: FC = 3.34; p = 3.06 E-4; MU-HF group: FC = 4.23; p = 1.30 E-4) (Figure 5A).