IKBKB and neoplasm: Moreover, NF-κB inhibition in lung epithelial cells by cell-specific ablation of IKK2 or p65/RelA or overexpression of IκBαSR significantly reduced tumour development in vivo in a Kras-driven model of lung adenocarcinoma (Meylan et al, 2009; Basseres et al, 2010; Xia et al, 2012).