RELA and skin neoplasm: Nevertheless, our results showing that mice with heterozygous epidermis-specific knockout of p65 (p65EHT) developed skin tumours similarly to p65FL mice after DMBA/TPA treatment (Fig 1D and E) demonstrate that this low level DNA damage induced by Cre recombinase did not have a measurable effect in DMBA-/TPA-induced skin tumorigenesis.