NFKB1 and neoplasm: In addition, inhibition of NF-κB signalling in mammary epithelial cells by expression of an IκBα super-repressor (IκBαSR) reduced tumour development in chemical medroxyprogesterone acetate (MPA)/7, 12-dimethylbenz(a)anthracene (DMBA)-dependent, and genetic PyVT- or ErbB2-driven models of mammary tumorigenesis (Pratt et al, 2009; Liu et al, 2010; Connelly et al, 2011).