RELA and neoplasm: Because NF-κB is also known to participate in inflammation and cell cycle control (Karin, 2006; Pasparakis, 2009; Baldwin, 2012), we hypothesized that p65 might act in keratinocytes to regulate TPA-induced tumour promotion and examined whether epidermis-specific p65 deficiency affected TPA-induced inflammatory epidermal hyperplasia.