In T-ALL, activated Notch1 regulates cell proliferation and apoptosis by modulating the level and activities of the related molecules/pathways such as Hes1, c-Myc, PI3K/AKT, and NF-κB through canonical (RBP-J-dependent) and/or non-canonical (RBP-J-independent) signals [10,11]. Here, HES1 is linked to acute lymphoblastic leukemia.