ROS scavenger TXN and its interacting protein TXNIP play an important role in regulating oxidative stress[39] and over-expression of TXNIP will induce G0/G1 cell cycle arrest.[40] Crosstalk between ER stress and ROS has previously been suggested.[41, 42] Our data showed that TXNIP was induced and TXN was reduced after pancreatic cancer cells were treated with IRE1α inhibitors. This evidence concerns the gene ERN1 and pancreatic neoplasm.