TP53 and neuroblastoma: To understand whether HDAC2 promoted survival in p53 wild type neuroblastoma cells, we first performed RT-PCR and immunoblot analysis of N-Myc and HDAC2 expression in the MYCN amplified Kelly (p53 wild type) and SK-N-BE(2) (p53 mutant) neuroblastoma cell lines after transfection with scrambled control siRNA, N-Myc siRNA (N-Myc siRNA-1 or siRNA-2) or HDAC2 siRNA (HDAC2 siRNA-1 or HDAC2 siRNA-2).