Among the 6 AOA tumours 5/6 had IDH1 mutations, and all 6 were judged to show methylation of MGMT Considering only tumours where we had results from both MGMT and IDH1/2 assays, among the AA 34/39 were judged to have methylation of MGMT and 31 of these 34 (91%) had IDH1 mutations. The gene discussed is IDH1; the disease is neoplasm.