We recently reported that receptor ligands, such as epidermal growth factor (EGF), heparin binding-epidermal growth factor (HB-EGF), and transforming growth factor-α (TGF-α), also activate EGFR as a bypass signal and induce crizotinib resistance in EML4-ALK NSCLC cells [11]. This evidence concerns the gene HBEGF and non-small cell lung carcinoma.