Very lately Shin et al. demonstrated temporal and bilateral basal ganglia hypermetabolism in 7/10 anti-LGI1 encephalitis patients (3 days to 2 years between symptom onset and diagnosis), which had not been compared to a matched control group [24], suggesting that the anti-LGI1-induced brain metabolic pattern may depend on the disease course, time point of diagnosis/therapy initiation and treatment regimen. This evidence concerns the gene LGI1 and encephalitis.