LGI1 and Down syndrome: Direct comparison between the above mentioned types of encephalitis likewise revealed distinct patterns with a relative hypometabolism in the precuneus, precentral, parietal, occipital and cingulate cortex (338–2616 voxels within Brodmann areas 2, 3, 4, 5, 6, 7, 10, 19, 20, 23, 26, 30, 39, 40) as well as regionally limited hypermetabolism in frontotemporal areas (40–449 voxels within Brodmann areas 10, 11, 20, 21, 22, 25, 30, 36, 38, 47, 48) of anti-NMDA receptor encephalitis patients compared to the anti-LGI1 associated syndrome (Figures 2C, 3C).