Again this variability of time points was caused by late admission of two patients to Hannover Medical School, however, 3/4 patients were at the clinical peak of the anti-LGI1 encephalitis at the time of PET with a mRS of 2.PET abnormalities of anti-LGI1 syndrome patients did not correspond to their MRI lesions that were not enhancing after gadolinium application: Multiple microangiopathic T2-hyperintensities in the subcortical white matter (patient 1) and bitemporal T2-hyperintensities (patient 2, Figure 1C-D). This evidence concerns the gene LGI1 and Down syndrome.