In anti-NMDA receptor encephalitis the regionally limited hypermetabolism in frontotemporal areas contrasted extensive hypometabolism in parietal lobes, whereas the anti-LGI1 syndrome is characterized by hypermetabolism in cerebellar, basal ganglia, occipital and precentral areas and minor frontomesial hypometabolism. This evidence concerns the gene LGI1 and encephalitis.