Furthermore, because TMEM106B genotype has been claimed to be a genetic modifier of FTLD [25–29], and to protect C9ORF72 carriers from FTD [25, 28, 29], we investigated whether this might influence both the distribution and severity of both DPR and TDP-43 pathologies in FTLD cases. The gene discussed is TARDBP; the disease is frontotemporal dementia.