TARDBP and Cerebellar atrophy: Such affected regions of the brain have hitherto not been considered to be involved in the (TDP-43) pathological process, and are brain regions which do not show obvious clinical repercussions, which might be anticipated if the DPR were principal in driving a neurodegenerative process, although there have been reports of cerebellar atrophy in expansion bearers [46, 47].