DPR were characteristically present in all FTLD and MND cases previously known to bear expansions in C9ORF72, but none were seen in any of the cases bearing GRN mutations, nor in any of the other FTLD cases or MND cases not known to be associated with any FTLD or MND linked mutation.In cases of FTD and FTD + MND, DPR were observed to be most frequent within the cerebral neocortex, hippocampus and cerebellum. This evidence concerns the gene GRN and frontotemporal dementia.