TARDBP and proteostasis deficiencies: In the present study, we too have determined how widely DPR are distributed throughout the brain in patients with FTLD and others with MND, and what cell types are affected, comparing the topographic distribution of DPR in patients with FTLD and MND in order to assess to what extent this distribution relates to the clinical expression of each disorder, and how it might relate to the underlying TDP-43 proteinopathy.