Secondly, neither the morphological appearance, nor relative severity, of TDP-43 immunoreactive changes differ in cases of FTLD bearing an expansion in C9ORF72 from that in non-expansion bearing cases of FTLD (ie sporadic forms of FTLD), or from cases of FTLD bearing mutations in GRN. These findings support the observations of Mackenzie and colleagues [24] who likewise noted no differences in either DPR or TDP-43 pathology between expansion bearing cases of FTD alone, FTD + MND or MND alone. This evidence concerns the gene C9orf72 and mild neurocognitive disorder.