These significant results, with respect to organ dysfunction, reveal severe morbidity among TLR4 rs11536889 GG patients (according to SOFA scores) and together with the fact that GG patients are assumed to present attenuated TLR4 expression[24], offer an explanation why synthetic TLR4 antagonists have failed to produce a clinical benefit in patients with severe sepsis[14,15]. Here, TLR4 is linked to Sepsis.