The observed severe hepatic dysfunction measured using the SOFA-hepatic score among TLR4 rs11536889 GG subjects, indicating severe hyperbilirubinemia in this group, is in agreement with recent findings reported by Deng et al.[16] that TLR4 signaling is essential for LPS clearance by hepatocytes during sepsis. The gene discussed is TLR4; the disease is Hyperbilirubinemia.