By contrast, the SFTPA2 haplotype 1A1 was found to be protective in a dominant model against the requirement for MV and the development of ARF and ARDS in the multivariate analysis (P = 0.015; OR, 0.16; P = 0.005; OR, 0.21; and P = 0.021; OR, 0.12). Here, SFTPA2 is linked to acute respiratory distress syndrome.