It has been shown that HCCs appear hypointens in HP images – most likely due to the down-regulation of OATP1 and the increased expression of MRP2 –, even though they lack the characteristic enhancement features of HCCs in early dynamic phases, for instance, due to the persistent portal venous blood supply in early HCC [23], [24]. This evidence concerns the gene ABCC2 and hepatocellular carcinoma.