Indeed, there are many lines of evidence indicating that the pathological amplification or rearrangement of chromosome 7p may very well underlie the increased abundance of MACC1 mRNA and is intimately associated with a concomitant overexpression of the protein throughout tumor growth, invasion, metastasis, and tumor recurrence [9], [27], [30], [41], [42] (also reviewed in [29]). The gene discussed is MACC1; the disease is neoplasm.