MACC1 and central nervous system cancer: Originally discovered in colon cancer, MACC1 overexpression has been demonstrated to promote tumor proliferation, invasion, and metastasis in a wide spectrum of solid tumors including gastrointestinal cancers (e.g. colon cancer [9], [10], gastric carcinoma [11]), hepatocellular carcinoma [12], [13], osteosarcoma [14], glioma [15], [16], lung [17], [18], [19], esophageal [20], pancreatic [21], ovarian [22], cervical and breast cancer [23] (reviewed in [24]).