As shown in Table 2, elevated MACC1 protein levels appeared to be associated with higher aggressiveness of RPC, with the AOD score of MACC1 in TNM stage Ta, I, II, and III-IV revealed as 0.0355±0.0247, 0.0563±0.0281, 0.0752±0.0264, and 0.0965±0.0185, respectively. Here, MACC1 is linked to familial reactive perforating collagenosis.