Positive MACC1 signals were detected in 66 of the 73 RPC cancer lesion samples (∼90.4%), as well as in 24 of the 32 ANRPET (∼75.0%) and 29 of the 41 NRPET (∼70.7%) samples we examined in this study. This evidence concerns the gene MACC1 and familial reactive perforating collagenosis.