TMPRSS3 and Hearing impairment: A novel homozygous missense mutation was identified in TMPRSS3 (MIM_605511), c.726C>G (p.Cys242Trp) that co-segregated with hearing impairment in family DFR24 (Figure 1) and was predicted to be probably damaging by Polyphen2 and deleterious by SIFT (Table 2).