GJB2 and deafness: The overall frequency of the two most common nonsense variants c.71G>A (p.Trp24*) and c.231G>A (p.Trp77*) of GJB2 in Pakistani deafness patients was obtained from the current (n = 125) as well as previously reported studies of Santos et al. [33] (n = 430) and Bukhari et al. [31] (n = 70).