IGHE and allergic disease: However, it considered there was ‘inadequate and insufficient’ evidence to infer associations with IgE-mediated allergies, but noted that “...the lack of consistency across epidemiology studies might have reflected a failure to identify susceptible subgroups.” In contrast, toxicological and controlled human exposure studies have shown strong evidence for a relationship between diesel particle exposure and IgE-mediated allergic responses [2], [3].