The interaction of ALS-specific antibodies with an unknown astrocytic membrane structure, mediated via phosphatidylinositol 3-kinase that integrates pathways of cell growth, proliferation, differentiation, motility, survival, and intracellular trafficking and can interact with around 50 Src homology domains containing cellular enzymes [54], could have a great impact on etiopathogenesis of ALS, thus stressing out the urge for further investigations. This evidence concerns the gene SRC and amyotrophic lateral sclerosis.