VEGFA and rheumatoid arthritis: At the same time, infiltrated inflammatory cells stimulate angiogenic process, by upregulating proangiogenic factors [100, 101] and activating NF-κB. Upregulation of Angs-Tie 2 [102] and VEGF [103] detected in chronic inflamed synovium and serum of RA patients emphasizes the interdependence of inflammation and angiogenesis in RA.