The increase of several immune cell-derived factors, such as interleukin-1 (IL-1), IL-6, IL-8, IL-10, and tumor necrosis factor alpha (TNF-α), has been described in tumor microenvironment: they sustain inflammatory process, contribute to tumor progression, and also exert proangiogenic activity [95, 96]. The gene discussed is IL10; the disease is neoplasm.