Animal models have been used to examine atherosclerotic pathology caused by periodontopathic bacteria. P. gingivalis has been reported by our and other groups to accelerate atherosclerosis in ApoE-KO or apolipoprotein E-deficient spontaneously hyperlipidemic (ApoEshl) mice [38–41]. A. actinomycetemcomitans bacteremia also aggravated atherosclerosis in ApoEshl mice [42, 43]. Here, APOE is linked to atherosclerosis.