Overcoming the insufficiency of the knowledge on the new gene OCIAD2 and studying the modular signaling mechanism from the given ligand to the pointed signature, the pbMOO approach successfully answered the question “how did the observed signature gene OCIAD2 get involved in ligand TGFβ stimulation signal,” and detailed the predicted pathways into the tumor microenvironment. The gene discussed is OCIAD2; the disease is neoplasm.