APC and colorectal carcinoma: In addition, the restoration of SFRPs in colon cancer cell lines carrying CTNNB1 or APC mutations resulted in the suppression of Wnt-dependent transcription and a higher rate of apoptosis, while the overexpression of Wnt-1 in CTNNB1 mutant cell lines increased Wnt-dependent transcription [19], and blocking Wnt-1 signaling induced apoptosis in human CRC cells containing downstream mutations [31].