In addition, high expression of WIF1 was significantly associated with big tumor diameters and deep invasion, while loss of SFRP1 expression was significantly associated with the left lesion site, deep invasion, and high TNM stage, implying that WIF1 and SFRP1 play different roles in the tumorigenesis of CRC, though both of them belong to similar secreted inhibitors of the Wnt pathway. This evidence concerns the gene WIF1 and neoplasm.